If a language is spoken and written by a powerful nation, it is incredibly hard to erase a language completely. There are people in the world who can read ancient babylonian and whatnot. But minor languages can be easily erased if conquered, especially if 'conquered' means a large inflow of population, as has been the case with the Han chinese' recent move to the west, thus threatening tibetan culture.
Alexander imposed greek and greek culture on the lands he cultured, thus creating a unified nation.. Of course, the whole successor thing kind of ruined that.
Good examples of languages being destroyed are gaulic and iberian.. Today those people speak spanish and french, both are essentially dialects of latin.
Still, it is possible for a language to survive. Noone knows where Basque is from, for example, and it is probably a very very old language. It has nothing to do with any other language known to man, except maybe Iberian as a distant relative.